Cocaine regulates sensory filtering in cortical pyramidal neurons

SC Murphy; L Godenzini; R Guzulaitis; AJ Lawrence; LM Palmer

Journal article

Cocaine regulates sensory filtering in cortical pyramidal neurons

SC Murphy, L Godenzini, R Guzulaitis, AJ Lawrence, LM Palmer

Cell Reports | Published : 2023

DOI: 10.1016/j.celrep.2023.112122

Abstract

Exposure to cocaine leads to robust changes in the structure and function of neurons within the mesocorticolimbic pathway. However, little is known about how cocaine influences the processing of information within the sensory cortex. We address this by using patch-clamp and juxtacellular voltage recordings and two-photon Ca2+ imaging in vivo to investigate the influence of acute cocaine exposure on layer 2/3 (L2/3) pyramidal neurons within the primary somatosensory cortex (S1). Here, cocaine dampens membrane potential state transitions and decreases spontaneous somatic action potentials and Ca2+ transients. In contrast to the uniform decrease in background spontaneous activity, cocaine has a..

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University of Melbourne Researchers

Lucy Palmer Author

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

We would like to acknowledge Sarah Chang for technical assistance. This work was supported by the NHMRC (APP1085708, L.M.P.) , the ARC (DP160103047, L.M.P.) , and the Sylvia and Charles Viertel Charitable Founda-tion (L.M.P.) . We acknowledge support from the Victorian State Government Operational Infrastructure Scheme.